By Jonathan J. Elsner, Israela Berdicevsky (auth.), Meital Zilberman (eds.)
Active implants are drug or protein-eluting implants that result in therapeutic results, as well as their commonplace job, for instance aid. This impact is completed via managed unlock of bioactive brokers to the encompassing tissue. This e-book offers a wide review of biomaterial systems utilized in inner and exterior drug-eluting implants. The publication is split into 4 elements:
1. Drug-eluting implants
2. Scaffolds for bone regeneration
3. Scaffolds in line with common polymers
4. New polymeric structures for energetic implants
The 18 experiences describe lively implants by way of matrix codecs, included medicines and their liberate profiles from the implants, in addition to cell-implant interactions and features. The impression of the method parameters at the micro or nano-structure and at the ensuing drug unlock profiles, mechanical and actual houses, and different proper houses, are emphasised. it's the first booklet to explain a wide diversity of energetic implants and current the frontier of information during this box. the hot biomaterial techniques for energetic implants defined during this e-book increase the instruments to be had for clinically vital biomedical applications.
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Extra resources for Active Implants and Scaffolds for Tissue Regeneration
FEMS Immunol. Med. Microbiol. 19, 307–314 (1997) 55. : Effect of different wound dressings on cell viability and proliferation. Plast. Reconstr. Surg. 117(7 Suppl), 110S–120S (2006) 56. : Evaluation of antibiotic-loaded collagen-hyaluronic acid matrix as a skin substitute. Biomaterials 25, 3689–3698 (2004) 57. : In vitro cytotoxity of silver: implication for clinical wound care. Burns 30(2), 140–147 (2004) 58. : Preparation and drug release activity of scaffolds containing collagen and poly(caprolactone).
Structure and morphology changes during in vitro degradation of electrospun poly(glycolide-co-lactide) nanofiber membrane. Biomacromolecules 4(2), 416–423 (2003) Tissue Adhesives as Active Implants Boaz Mizrahi, Christopher Weldon and Daniel S. Kohane Abstract Tissue adhesives are substances that hold tissues together, and could be broadly applicable in medicine and surgery. In appropriate circumstances, such materials could be attractive alternatives to sutures and staples since they can be applied more quickly, causes less pain and may require less equipment.
1). The time-dependent antimicrobial efficacy of these antibiotic-eluting wound dressing formulations was tested in vitro by the following two complementary methods: 1. The corrected zone of inhibition test (CZOI) , which is also termed the disc diffusion test. According to this method presence of bacterial inhibition in an area that exceeds the dressing material (CZOI [0) can be considered beneficial. This method gives a good representation of the clinical situation, where the dressing material is applied to the wound surface, allowing the drug to diffuse to the wound bed.
Active Implants and Scaffolds for Tissue Regeneration by Jonathan J. Elsner, Israela Berdicevsky (auth.), Meital Zilberman (eds.)