By Günter Obe, H.H. Evans, D. Frankenberg, M. Frankenberg-Schwager, E. Gebhart, W. Köhnlein, R.H. Nussbaum, D.G. Papworth, J.R.K. Savage, R.-D. Wegner
Applied genetic examine, genetic toxicology and mutation study examine the mutagenicity and cancerogenicity of chemical substances and different brokers. everlasting mutation in genes and chromosomes, should be triggered by way of a plethora of brokers, together with ionizing and nonionizing radiations, chemical substances, and viruses. one of the features mentioned by way of Advances in Mutagenesis Research are (1) the knowledge of the molecular mechanisms resulting in mutations, and (2) the prevention of a inconsiderate advent of mutagenic brokers into the environment.
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The authors suggest that the induction of SCE therefore occurs by an indirect mechanism (Nagasawa et al. 1990b). 1 Gy for a-radiation and approximately 2 Gy for X-radiation: The induced SCE declined at higher doses of both types of radiation (Nagasawa et al. 1990a). , Aghamohammadi et al. 1988). If chromosome breaks are examined in the G 1 period of the cell cycle immediately after exposure to a-radiation, using the technique of premature chromosome condensation (PCC), more breaks are observed than when the observation is made at the subsequent metaphase.
2 Energy Deposition by Alpha Particles . . . . . . . . . . . . . . . 3 Evidence That Irreparable Lesions Are Induced by Alpha Particles . . . . . . . 4 Induction of DNA Double-Strand Breaks by Alpha Radiation . . . . . . . . . 5 Chromosomal Damage Induced by Alpha Radiation . . . . . . . . . . . 6 Mutagenicity of Alpha Radiation . . . . . . . . . . . . . . . . . 7 Characterization of Mutational Lesions Induced by Alpha Radiation .
Base change mutations induced in the genomic DNA of eukaryotic cells by low-LET irradiation have been found to occur at random, with no marked specificity for individual bases or for the induction of transitions vs transversions (Das et al. 1986; Grosovsky et al. 1988; Miles and Meuth 1989). However, the mutational spectra were not random in the case of the supF gene carried by the extrachromosomal shuttle vector pZ 189 following irradiation either in vitro or after transfection into human cells (Jaberaboansari et al.
Advances in Mutagenesis Research by Günter Obe, H.H. Evans, D. Frankenberg, M. Frankenberg-Schwager, E. Gebhart, W. Köhnlein, R.H. Nussbaum, D.G. Papworth, J.R.K. Savage, R.-D. Wegner